Review ArticleOpen Access

Human Coronaviruses: Genetics, Virulence Factors and Pathophysiology, Diseases’ Epidemiology

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DOI: 10.23958/ijirms/vol06-i10/1232· Pages: 698 - 712· Vol. 6, No. 10, (2021)· Published: October 8, 2021
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Abstract

Coronaviruses are pathogens for both animals and humans. The recent Coronavirus Disease (Covid-19), caused by a novel Coronavirus (SARS-CoV-2), outbreak that took place in Hubei (Wuhan, China) from December 2019 aroused numerous questions regarding the nature and the origin of the SARS-CoV-2. Literature review of the main publications from scientific data bases was undertaken. These data revealed similarities of symptoms and identity of genome with the SARS-CoV. In this review, the genetics and virulence factors of coronaviruses, the disease pathophysiology and epidemiology were examined.

Keywords

Pathophysiologyepidemiologycoronavirus diseasesgenomeSARS-CoV
Author details
Gnatoulma Katawa
Advanced School of Biological and Food Techniques (ESTBA) / Laboratory of Microbiology and Food Quality Control / Research Unit in Immunology and Immunomodulation (UR2IM), University of Lomé, Togo
✉ Corresponding Author
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Banfitebiyi Gambogou
1Advanced School of Biological and Food Techniques (ESTBA) / Laboratory of Microbiology and Food Quality Control / Research Unit in Immunology and Immunomodulation (UR2IM), University of Lomé, Togo. 2Togolese Institute for Agronomic Research (ITRA), Togo
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Christèle T. Nguepou
Advanced School of Biological and Food Techniques (ESTBA) / Laboratory of Microbiology and Food Quality Control / Research Unit in Immunology and Immunomodulation (UR2IM), University of Lomé, Togo
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Essoham Ataba
Advanced School of Biological and Food Techniques (ESTBA) / Laboratory of Microbiology and Food Quality Control / Research Unit in Immunology and Immunomodulation (UR2IM), University of Lomé, Togo
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Manuel Ritter
Institute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn (UKB), Bonn, Germany
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Eya H. Kamassa
Advanced School of Biological and Food Techniques (ESTBA) / Laboratory of Microbiology and Food Quality Control / Research Unit in Immunology and Immunomodulation (UR2IM), University of Lomé, Togo
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Fagdéba D. Bara
Advanced School of Biological and Food Techniques (ESTBA) / Laboratory of Microbiology and Food Quality Control / Research Unit in Immunology and Immunomodulation (UR2IM), University of Lomé, Togo
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Simplice D. Karou
Advanced School of Biological and Food Techniques (ESTBA) / Laboratory of Microbiology and Food Quality Control / Research Unit in Immunology and Immunomodulation (UR2IM), University of Lomé, Togo
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Yaovi Ameyapoh
Advanced School of Biological and Food Techniques (ESTBA) / Laboratory of Microbiology and Food Quality Control / Research Unit in Immunology and Immunomodulation (UR2IM), University of Lomé, Togo
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