International Journal of Innovative Research in Medical Science
https://www.ijirms.in/index.php/ijirms
<p>International Journal of Innovative Research in Medical Science is a Peer-reviewed, Open Access journal that providing rapid publication of high-quality valuable research in all the areas of medical sciences, clinical research and medicine. Journal publishes original research articles, review articles, case reports and clinical studies covering recent innovative in medical sciences and related disciplines.</p>IJIRMS Publicationen-USInternational Journal of Innovative Research in Medical Science2455-8737<p>Creative Commons License All articles published in International Journal of Innovative Research in Medical Science are licensed under a Creative Commons Attribution 4.0 International License.</p>Ladder Distribution of LAIV Reassortment between Vero Adaption Attenuated Strain and Wide Type Highly Virulent Influenza Virus Strain
https://www.ijirms.in/index.php/ijirms/article/view/1818
<p>It described the “ladder distribution” of live attenuated influenza vaccine (LAIV) reassortment between Vero cells adaption attenuated strain and wide type-high virulent influenza virus strains by the reverse genetics approach. That gene constellation could save the immunogenicity (imm) of the parental strain and make new reassort virus strain attenuation (<em>att</em>) characteristics for further vaccine using, rapidly, not only seasonal vaccine but also pandemic flu vaccine.</p>ze liuJinhai HuangGao Hui
Copyright (c) 2024 Liu Ze, Huang Jinhai, Gao Hui
https://creativecommons.org/licenses/by/4.0/
2024-03-212024-03-2190316416710.23958/ijirms/vol09-i03/1818The Use of Hyaluronic Acid in Reducing Postoperative Complications in Minor Oral Surgery: A Review
https://www.ijirms.in/index.php/ijirms/article/view/1842
<p><strong><em><u>Aim:</u></em></strong> Hyaluronic acid (HA) is a major carbohydrate component of the extracellular matrix, and it is distributed widely throughout connective, epithelial tissues, and neural tissues. Since HA is used to promote healing following dental treatments, it has lately gained recognition as an adjuvant treatment for minor oral surgery. This review aims to give practitioners the most recent possible information regarding HA as an adjuvant treatment for minor oral surgery. <strong><em><u>Method:</u></em></strong> A literature search of PubMed and Google Scholar for obtaining the relevant studies revealed an initial screening of 54 studies, and after excluding the out-of-scope, the final included studies were 29 studies. <strong><em><u>Conclusion:</u></em></strong> Most reviewed studies reported positive associations with the usage of HA in treating AO, edema, pain, and trismus due to its inherent favorable properties. However, the data suggest that HA interferes with bleeding management.</p>Alomar, F. AhmedAlayed, S. SaudNaitah, N. AbdulazizAlkadhi, A. AbdullahAlhassoon, H. AbdulazizAlshahrani, S. KhalidAlshahrani, S. TurkiAlaman, A. KhalidAlsultan, M ZiyadIbtisam K. AlmubarakReem A. AlbluwiEbtehal Albeshir
Copyright (c) 2024 Alomar, F. Ahmed, Alayed, S. Saud, Naitah, N. Abdulaziz, Alkadhi, A. Abdullah, Alhassoon, H. Abdulaziz, Alshahrani, S. Khalid, Alshahrani, S. Turki, Alaman, A. Khalid, Alsultan, M Ziyad, Ibtisam K. Almubarak, Reem A. Albluwi, Ebtehal G. Albeshir
https://creativecommons.org/licenses/by/4.0/
2024-03-102024-03-1090315015310.23958/ijirms/vol09-i03/1842Exploring the Intersection: Type 2 Diabetes and Its Influence on Mental and Psychosocial Well-Being: Mini Review
https://www.ijirms.in/index.php/ijirms/article/view/1849
<p>This systematic review examines the common risk factors associated with cognitive impairment, depression, and psychosocial issues in individuals with type 2 diabetes (T2D), aiming to highlight the interrelated aspects of these conditions. Recognizing the elevated risk of cognitive disorders, including dementia, and their subsequent impact on hospitalization, falls, and premature mortality in T2D patients, we meticulously searched electronic databases for relevant studies published from 2016 onwards, complemented by manual searches in leading journals. Out of the initial pool, we are focusing on biological, psychological, social, and pharmacological determinants leading to neuropsychological complications in T2D.</p> <p>The analysis revealed consistent risk factors across cognitive impairment, depression, and psychosocial challenges, including comorbid conditions, dysglycemia, sex differences, elevated anxiety levels, educational and socio-economic status, and medication effects. Notably, disease duration, obesity, and age were underscored as significant contributors to both cognitive and depressive disorders. The lack of a strong support network further emerged as a pivotal risk factor, exacerbating psychosocial and depressive symptoms. These findings underscore the complexity of T2D management, highlighting the necessity for comprehensive care approaches that incorporate psychosocial support, patient education, and tailored treatments. This review emphasizes the importance of addressing multifaceted risk factors to enhance the overall outcomes and quality of life for individuals with T2D.</p>Maarja RandväliToomas Toomsoo
Copyright (c) 2024 Maarja RANDVÄLI, Toomas TOOMSOO
https://creativecommons.org/licenses/by/4.0/
2024-03-202024-03-2090315415710.23958/ijirms/vol09-i03/1849Thyroid Troubles Unveiled: A Rare Case of Hyponatremia Secondary to Hypothyroidism
https://www.ijirms.in/index.php/ijirms/article/view/1839
<p>Thyroid hormones, produced by the thyroid gland, play various roles in the body. Essential for fetal development. There are many complications, one of which is rare: hyponatremia, an electrolyte imbalance characterized by low levels of sodium in the body. We present a case of a 69-year-old man who arrived at the emergency department after falling from the sofa and experiencing subsequent memory loss. The sodium level upon arrival was 114 mmol/L. After ruling out other potential causes of hyponatremia, the final diagnosis was hypothyroidism. After treating hypothyroidism, the sodium level began to rise again. It is essential to check thyroid function when a patient with low sodium and clinical symptoms of altered mental status is admitted to the hospital.</p>Jafrin Sadiq Abdul RazackSyeda Juveria HussainiSaud Khaled AldoseriSahil Asgar AliMohamed Elnaily
Copyright (c) 2024 Jafrin Sadiq Abdul Razack, Syeda Juveria Hussaini, Saud Khaled Aldoseri, Sahil Asgar Ali, Mohamed Elanily
https://creativecommons.org/licenses/by/4.0/
2024-03-022024-03-0290314414610.23958/ijirms/vol09-i03/1839An Ongoing Concern of Diabetic Management with SGLT2i - Its Potential Medico-Legal Implication
https://www.ijirms.in/index.php/ijirms/article/view/1843
<p>Diabetic Ketoacidosis (DKA) is a life-threatening diabetic emergency. There is now an emerging risk of DKA because of a potential adverse effect of the new diabetic medication - Sodium Glucose Transporter 2 inhibitor (SGLT2i) that can lead to diabetic ketoacidosis. This paper shares our experience of unexpected events in two diabetic patients taking SGLT2i, resulting in urgent hospitalization in one case and medical litigation in the other. It also brings to the doctors' attention that ketone breath sensors are now available to diagnose DKA quickly and accurately. They can offer a non-invasive approach to detecting and monitoring DKA in diabetic patients; hopefully, it could have averted similar events and prevented medical litigation in the future.</p>Wu Shun Felix WongVincent Tok Tai Yeung
Copyright (c) 2024 Wu Shun Felix Wong, Vincent Tok Fai Yeung
https://creativecommons.org/licenses/by/4.0/
2024-03-032024-03-0390314714910.23958/ijirms/vol09-i03/1843The Carotid Intima Medial Thickness Among Type 2 Diabetes Mellitus and Controls: A Cross Sectional Study
https://www.ijirms.in/index.php/ijirms/article/view/1841
<p><strong><em><u>Introduction:</u></em></strong> In Nigeria, the prevalence of diabetes mellitus has been on increasing steadily. With the increasing prevalence of diabetes mellitus, one expects higher rate of its complications including carotid atherosclerosis (which may present with silent infarct, transient ischemic attack, or ischemic stroke) and coronary artery disease. The common link between carotid atherosclerosis and coronary artery disease is atherosclerotic cardiovascular disease with increase intimal medial thickness. This study evaluated medial intima thickness of among Diabetes at the University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria. <strong><em><u>Methods and Materials:</u></em></strong> The study was a descriptive cross-sectional, to assess relationship between peripheral artery disease and carotid atherosclerosis among type 2 diabetic subjects in UPTH using the ankle brachial pressure index and carotid intima-medial thickness. 110 diabetic subjects, and 110 age and gender matched non-diabetic, controls were recruited for the study. Type 2 diabetic subjects and controls that met the inclusion criteria and consented were recruited consecutively as they met the inclusion criteria.</p> <p>Demographic data, anthropometric measures were taken and recorded. Using a structured questionnaire, information on medical history, physical examination and examination of carotid intima-medial thickness were measured and documented. Confidentiality was maintained throughout the 13 months period of the study. Data obtained were checked for errors and corrected before being analyzed using the statistical package for social sciences software 20.0 (SPSS 20.0).</p> <p><strong><em><u>Results:</u></em></strong> There were 67 females and 43 males with type 2 diabetes, while 61 Females and 49 males served as controls. The mean age for the diabetic subjects was 54.85 ± 10.09, while that for the controls was 52.86 ± 10.31. The mean duration of diabetes mellitus was 6.24 ± 4.53. The patient with CIMT more than 1mm account for 19.1% of the subjects, while the controls had 7.3% Th is statistically significant with a p-vale of <0.001.</p> <p>Increased thickness of the carotid intima-medial was found to be significantly associated, increasing duration of diabetes.</p> <p><strong><em><u>Conclusion:</u></em></strong> CIMT is more common in diabetic patients compared to age and gender-match controls. Most subjects with increased CIMT are asymptomatic.</p>EMMANUEL AUCHI EDAFEMaclean R Akpa
Copyright (c) 2024 Emmanuel Auchi Edafe, Maclean R Akpa
https://creativecommons.org/licenses/by/4.0/
2024-03-022024-03-0290313814310.23958/ijirms/vol09-i03/1841Heart Health at the Frontline: A Study on Hypertension and Prehypertension involving Healthcare Staff of a Tertiary Care Hospital
https://www.ijirms.in/index.php/ijirms/article/view/1845
<p><strong><em><u>Background:</u></em></strong> Hypertension, a major public health concern worldwide, affects individuals across various professions, including healthcare workers. This study aims to estimate the prevalence of hypertension and prehypertension among healthcare staff working at a tertiary care hospital and assess the associated risk factors. <strong><em><u>Aims and Objectives:</u></em></strong> To find prevalence of hypertension and prehypertension and its link with various demographic variables among study population. <strong><em><u>Settings and Design:</u></em></strong> A cross-sectional study was conducted at the tertiary care hospital. <strong><em><u>Methodology:</u></em></strong> A cross-sectional study was conducted, including a representative sample of healthcare staff. Data on demographics, lifestyle factors and blood pressure measurements were collected. The prevalence of hypertension and prehypertension was estimated, and significant risk factors were identified. <strong><em><u>Statistical analysis used:</u></em></strong> One-way ANOVA test and Chi square test were used to compare different variables. <strong><em><u>Results:</u></em></strong> Out of total study participants 38.02% were males and 61.98% were females. Among all the continuous variables included, weight, BMI, waist circumference and systolic BP and diastolic BP showed significant association. Among all the non- continuous variables included, monthly family income, place of residence, education, post in current occupation, use of extra salt in diet and habit of doing regular exercise showed significant association. <strong><em><u>Conclusions:</u></em></strong> The study showed age, weight, BMI, waist circumference, place of residence, education, post at workplace, monthly family income, use of extra salt in diet and habit of exercise were strongly associated with blood pressure and were better potential predictors of risk for hypertension and prehypertension than the other indices tested.</p>Dr. Malay SavaliaDr. Pravin ParmarAditi SinghAkshat JainSaurabh AlweAman DeswalAmartya Banerjee
Copyright (c) 2024 Malay P. Savalia, Pravin D. Parmar, Aditi Singh, Akshat Jain, Saurabh Alwe, Aman Deswal, Amartya Banerjee
https://creativecommons.org/licenses/by/4.0/
2024-03-212024-03-2190315816310.23958/ijirms/vol09-i03/1845